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Using an uneven grid with the CMS

Is it possible to use an uneven grid for content (i.e three columns in top row, two in second, three in third) with the CMS? In other words, if the client were to add another three posts via the CMS, is it possible to continue this uneven approach? i.e the next row in this sequence would automatically have two columns, the row after would have three and so on?

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