For text formatting:
Create custom CSS snippet to include columns:
You may want to look at CSS columns as an option for text flow and to increase onscreen readability. CSS Multiple Columns
Design Inspiration:
I would also look for inspiration in traditional editorial design from newspaper to tabloid sized magazines as they have spent decades refining the craft of great page design and editorial flow and you can do some creative adaptation to digital. I can look up some of my bookmarks and pass along some of the stuff that inspires me if you like.
Full Screen Reflow:
The Flipboard app has an article on the engineering behind its app (will locate it and follow up with a link). I am not recommending you attempt to create something on that scale 
but the page layouts and the way they customize reflow is really inspiring from a page composition / responsive design approach. They have accomplished some genius in their design in my opinion especially to be remapping existing content into a new personal user curated medium. It is a beautiful app.
Moving content beyond the container:
Look into a wide screen media query as it can open up some nice options for larger headings and layout size rewrites for large screen desktops. You can rewrite (override) any CSS property for a class inside the widescreen media query) Lose the container and build your own. Using larger media queries in combo with fluid full screen layouts (percentage based widths) should add a great deal with a little experimentation. You will have to publish to preview the rewrites for larger sizes (as well as for the CSS columns above), but that is really easy to do.
This is something I am very interested in and am beginning to experiment with myself. Happy to follow up with some links. Nudge me if I forget @Diu