I don’t think this should be any headache. You can achieve this with Webflow. Design is iterative and I know as you go ahead building it you will review your concept and trash the unnecessary. Just keep things simple and structured in the beginning.
You can use columns as advised, but if you desire more design freedom, make use of divs and inline-block.
If you need assisted, you can sent me private mail and we can do this together for a token.