How do i make an unperfect image grid

Hi there,

I wan’t to create a grid of CMS items whichs is in a non-alligned format.
I have a mockup of what i this here:

Did you tried like a 12grid and set each Div ex. 1-5 6-12 3-7 5-10

Can you point to me what you mean?
Maybe a screenshot of the proposed setup?

Preview Link

Maybe with this images, you could figure out